Cefalexin or cephalexin is an antibiotic useful
for the treatment of a number of bacterial infections. It is taken by mouth and is active against
gram positive bacteria and some gram negative bacteria. It is in the class of first generation cephalosporins
and has similar activity to other agents within this group including the intravenous agent
cefazolin. Cefalexin is used to treat a number of bacterial
infections including: middle ear infections, strep throat, bone and joint infections, pneumonia,
skin infections, and urinary tract infections. It may be used to prevent bacterial endocarditis. It is ineffective against methicillin-resistant
Staphylococcus aureus. It may be used in those who have mild or moderate
allergies to penicillin but is not recommended is those with severe allergies. It has no effect against viral infections. Possible side effects include: allergies,
stomach and intestinal upset, and Clostridium difficile diarrhea among others. It is pregnancy category B in the United States
and category A in Australia meaning that there is no evidence of harm after being taken by
many pregnant women. Use during breast feeding is okay. It is suitable for use in children and those
over 65 years of age. Doses may need to be decreased in those with
kidney problems. In 2012, cefalexin was one of the top 100
most prescribed medications in the United States. In Australia it is one of the 15 most prescribed
medications. It was developed in 1967 and first marketed
in 1969 and 1970 by a number of companies including Glaxo Wellcome and Eli Lilly and
Company under the names Keflex and Ceporex among others. It is available as a generic drug under several
other trade names and is not very expensive. It is on the World Health Organization’s List
of Essential Medicines, a list of the most important medication needed in a health system. Medical uses Cefalexin is used to treat a number of infections
including: otitis media, streptococcal pharyngitis, bone and joint infections, pneumonia, cellulitis,
and urinary tract infections. It may be used to prevent bacterial endocarditis. It can also be used for the prevention of
recurrent urinary-tract infections. Cefalexin does not treat MRSA, or methicillin-resistant
staphylococcus aureus. Cefalexin is a useful alternative to penicillins
in patients with penicillin intolerance. For example, penicillin is the treatment of
choice for respiratory tract infections caused by Streptococcus, but cefalexin may be used
as an alternative in penicillin intolerant patients. Caution must be exercised when administering
cephalosporin antibiotics to penicillin sensitive patients, because cross sensitivity with beta-lactam
antibiotics has been documented in up to 10% of patients with a documented penicillin allergy. Adverse effects
The most common adverse effects of cefalexin, like other oral cephalosporins, are gastrointestinal
disturbances and hypersensitivity reactions. Gastrointestinal disturbances include nausea,
vomiting, and diarrhea. Hypersensitivity reactions include skin rashes,
urticaria, fever, and anaphylaxis. Pseudomembranous colitis has been reported
with use of cephalexin. Symptoms of an allergic reaction include rash,
itching, swelling, trouble breathing, or red, blistered, swollen or peeling skin. Overall, cefalexin allergy occurs in less
than 0.1% of patients, but it is seen in 1% to 10% of patients with a penicillin allergy. Drug interactions
Like other beta-lactam antibiotics, renal excretion of cefalexin is delayed by probenecid. Alcohol consumption does not have a negative
interaction with cefalexin, but reduces the rate at which it is absorbed. Mechanism of action
Cefalexin is a beta-lactam antibiotic. It is bactericidal and acts by inhibiting
synthesis of the bacterial cell wall. It is most active against gram-positive cocci,
and has moderate activity against some gram-negative bacilli. References External links
U.S. National Library of Medicine: Drug Information Portal – Cephalexin

2 thoughts on “Cefalexin

  1. What does the pill look like because the one I got looks different and according to manufacturer thats not the pill I got

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